5 ECTS credits
150 h study time
Offer 1 with catalog number 4023428ENR for all students in the 1st semester at a (E) Master - advanced level.
HOC
The course Toxicology and 3R-alternative methods contains the basic principles and definitions that are used in toxicology. First, attention is given to the question what toxicity means and under which conditions it can occur. Qualitative as well as quantitative aspects are discussed and acute and chronic toxicity are taken up. Special attention is given to 3R-alternative methods for toxicity testing. Then these basic principles are applied for organic solvents and in particular alcohols (ethanol, methanol). Special attention also goes to abuse of pharmaceuticals and drugs.
WPO
The Lab work is composed of:
- Toxicological analyses of body fluids (qualitative and quantitative) using different techniques (e.g. spectrophotometry, GC, TLC).
- Toxicological problems.
- A written task on a timely toxicological problem.
- Audiovisual package 3R-alternative methods.
- Attendance to the practical courses is compulsory.
- Participation to the course Toxicology and 3R-alternative methods is only possible if the registration is completed before the start of the first week of the first semester !!
- The background of the exercises and protocols must be studied before the start of each lab day.
HOC
The basic concepts of toxicology are defined and it is learned how the qualitative and quantitative evaluation of toxicological effects are carried out. Special attention is given to the use of 3R-alternative methods for toxicity testing. The basic concepts of toxicology are then used in the discussion of various groups of toxins and drugs. Also the abuse of drugs and medicines is discussed.
WPO
Toxicological analyses are carried out to illustrate the theoretical lessons. Some insight is gained in the relationship biotransformation and toxicity of pharmaceuticals and toxic compounds.
The final grade is composed based on the following categories:
Oral Exam determines 67% of the final mark.
PRAC Practical Assignment determines 33% of the final mark.
Within the Oral Exam category, the following assignments need to be completed:
Within the PRAC Practical Assignment category, the following assignments need to be completed:
The final mark is calculated as the weighted average of the mark obtained for the Oral examination and the evaluation of the WPO: oral exam of HOC 2/3 and evaluation of the WPO 1/3. If a partial grade is less than or equal to 8/20, the final grade cannot be higher than the lowest partial grade. The partial mark WPO is determined as the average of the results obtained for Lab Work (1/2) and the WPO Exam (1/2). The result for WPO Lab Work is determined as the average of the results obtained on the lab reports of the tests (1/2), and interrogations and a task performed (1/2). The WPO Exam grade is determined by the average of the results obtained on theoretical questions related to the practical course (1/3), toxicological problems (1/3) and a practical test (1/3). The WPO exam is taken during the class hours foreseen for the WPO. Failing for the WPO does not exclude participation to the oral exam in the first session. A partial exemption for the 2nd session for the Oral exam and the WPO can be obtained if at least 10/20 was obtained for that part. WPO Lab work (lab days + reports + interrogations + task) and the practical test of the WPO Exam cannot be redone. If this is insufficient (<10/20), then this mark is taken into account for the calculation of the final result for the 2nd session. A partial exemption for the next academic year for the Oral exam and the WPO can be obtained if at least 10/20 was achieved for that component.
Whenever a student is legitimately absent during the practical courses, the docent will decide whether the student has to catch up the respective lab tests or has to make an alternative task, if necessary for the second session.
Whenever a student is illegitimate absent during the practical courses, he/she has to follow the whole WPO session again during the next academic year and will as such be automatically referred to the 1st exam session of the next academic year.
This offer is part of the following study plans:
Master of Pharmaceutical Care: Standaard traject NIEUW (only offered in Dutch)
Master of Drug Development: Pharmacist (only offered in Dutch)
Master of Drug Development: AR without officinastage (only offered in Dutch)