3 ECTS credits
90 u studietijd
Aanbieding 1 met studiegidsnummer 1024214ANR voor alle studenten in het 2e semester met een inleidend bachelor niveau.
Lectures: This course builds on previous courses of the Bachelor of Science program, including ‘Organic Chemistry: Structural Aspects’ and ‘Organic Chemistry: Reactivity’. The main goal of this course consists of applying different kinds of organic reactions in a logical and strategic manner to obtain target (bioactive) molecules via multistep syntheses. Whereas previous courses focused on specific structural features of organic molecules and their basic reactivity, this course serves mostly to identify the ideal string of chemical reactions to quickly access predefined chemical compounds. For this reason, the course serves mostly to strategically apply previous knowledge through the basic concepts of RETROSYNTHESIS rather than expanding the vocabulary of chemical conversions. Nonetheless, new reactions and strategies are still studied (e.g. enolate chemistry, use of protecting groups, chemoselective conversions) and applied.
Practical sessions: The first laboratory exercises consist of the separation, purification and identification of two or three unknown compounds in a mixture. The following (multistep) synthesis subjects vary from year to year, depending on the supervisor. Examples of chemical steps are a malonate synthesis (synthesis of beta-methylphenylalanine) or a phase transfer-catalyzed alkylation of (diphenylmethylene)glycine ethyl ester, an oxidation reaction (indene to 2-indanone), a Strecker-type synthesis (2-aminoindane-2-carboxylic acid) and a N-protection step. A focus is being placed on biologically active compounds or useful synthetic intermediates that fit ongoing research of the Research Group of Organic Chemistry.
In an introductory and compulsory session the essentials of lab safety are taught. Additionally, the students are introduced in the names and use of glassware items (e.g. reflux setup, distillation, extraction, filtration, evaporation, crystallisation, cleaning).
De beoordeling bestaat uit volgende opdrachtcategorieën:
Examen Mondeling bepaalt 60% van het eindcijfer
Examen Praktijk bepaalt 40% van het eindcijfer
Binnen de categorie Examen Mondeling dient men volgende opdrachten af te werken:
Binnen de categorie Examen Praktijk dient men volgende opdrachten af te werken:
The total score/grade is composed of two parts, namely the subscore reached after evaluation of the practical sessions and the score obtained after the oral exam (with written preparation). The oral exam will mainly consist of solving exercises via the disconnection approach. For the evaluation of the practicals, the following categories and attitudes are quoted: reports, answer to questions during the exercises, preparation, performance in the laboratory, including correct experimental setup, cleanliness and organisation. Students who are illegitimately absent cannot retake the practical exercises and are quoted pro rata the amount of missed exercises. Students who were illegitimately absent on two practical sessions are excluded from the exam. There is no possibility to redo the practical exercises in the 2nd examination session (August/September).
Deze aanbieding maakt deel uit van de volgende studieplannen:
Bachelor in de bio-ingenieurswetenschappen: Standaard traject