6 ECTS credits
160 h study time
Offer 1 with catalog number 4001738FNR for all students in the 1st semester at a (F) Master - specialised level.
This study part introduces the students to the basics of the analysis, the design and the optimization of bioreactors. For this purpose, the students are familiarized with the principles modelling of stoechiometry, kinetics, transport and the establishment of mass balances. This study part provides the basis for other courses of industrial microbiology, environmental and food technology
Contents
0. Introduction
What is biochemical engineering
Bioreactor classification, examples.
1. Stoechiometry and thermodynamics. Kinetics.
2. Homogeneous Ideal Flow Reactors
Monod chemostat, batch, plug flow, contamination, mutation, incomplete mixing, comparison of reactor types
3. Non-Ideal Flow Reactors
4. Gas-liquid reactors
Gas liquid transport, oxygen transport, models, correlations, measurement, solid liquid transport
5. Heterogeneous reactors
Diffusion resistance, models, reactor types
Immobilized cell systems
6. Sterilisation
Models, death rates, equipment
Student text notes available on the learning platform.
Complementary study material:
BAILEY, J.E.; OLLIS, D.F., Biochemical Engineering Fundamentals (2nd. ed.),
New York, Mc Graw Hill, 1986.
DUNN, I.J., HEINZLE, E., INGHAM, J., PRENOSIL, J.E., Biological Reaction Engineering, VCH Verlag, 1992
NIELSEN, J., VILLADSEN, J., Bioreactor Engineering Principles, Plenum Press, 1994
LEE, J.M., Biochemical Engineering, Prentice Hall, 1992
SHULER, M.L., KARGI, F., Bioprocess Engineering, Prentice Hall, 1992
ASSENJO, J.A., MERCHUK, J.C., Bioreactor System Design, Marcel Dekker, 1995
This study part introduces the students to the basics of the analysis, the design and the optimization of bioreactors. For this purpose, the students are familiarized with the principles modelling of stoechiometry, kinetics, transport and the establishment of mass balances. This study part provides the basis for other courses of industrial microbiology, environmental and food technology
Objective
The student should be able to analyse quantitatively a bioprocess and develop balance equations, select a reactortype and operation mode for a given bioconversion. Computer simulation of a process by mathematical modelling is taught and the students skills in this are tested.
The final grade is composed based on the following categories:
Written Exam determines 100% of the final mark.
Within the Written Exam category, the following assignments need to be completed:
The exam is written with opportunity for oral discussion during the exam. The exam is closed book and will contain three or four main questions, each with an equal weight. Per question a mix of subquestions is posed. These sub-questions represent a mix of elements learned during the theoretical course and the practical sessions and aim at checking whether:
-the student understands the meaning of each variable in the equations etablished during the lectures and the reason for their presence
-the student can apply the solution methods to geometries and situations similar to those treated during the lectures
-the student can make cross-references between different parts of the course
-the student can choose the optimal reactor design and calculate the required reactor residence time and volume for a given application.
This offer is part of the following study plans:
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Medical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Molecular Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Agrobiotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Food Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Chemical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Biochemical Biotechnology (only offered in Dutch)