5 ECTS credits
125 h study time

Offer 1 with catalog number 4002173ENR for all students in the 2nd semester at a (E) Master - advanced level.

Semester
2nd semester
Enrollment based on exam contract
Impossible
Grading method
Grading (scale from 0 to 20)
Can retake in second session
Yes
Taught in
English
Faculty
Faculty of Medicine and Pharmacy
Department
Supporting clinical sciences
Educational team
Serge Muyldermans
Geert Raes
Nick Devoogdt (course titular)
Marleen Keyaerts
Sophie Hernot
Matthias D'Huyvetter
ChloƩ ACKAERT
Catarina Xavier
Activities and contact hours
30 contact hours Lecture
50 contact hours Seminar, Exercises or Practicals
50 contact hours Independent or External Form of Study
Course Content

Antibodies have an exceptional competency to recognize specific molecules via their antigen-binding region. Therefore, they play an important role in cancer imaging and therapy. Indeed, antibody-based imaging can provide a sensitive way to non-invasively visualize, characterize and quantify molecular and cellular processes, and antibody-based therapies have proven to be successful alternatives to traditional cancer treatments. However, antibodies also have their shortcomings and limitations and are the subject of molecular engineering to generate more optimal compounds.

This course aims to provide an extensive overview of applications of antibodies and antibody-fragments in various applications of molecular imaging and targeted therapies. The core of this knowledge will be provided during a one-week intensive workshop where national and international experts will give an introduction of their respective research field during 1,5h lectures. The lectures will be supplemented with practical hands-on sessions and discussion fora that aim to dig deeper in particular research topics. The one-week workshop will be preceded by an introductory lecture and also a feedback session is foreseen.

This course aims to develop students into critical, self-sufficient and confident researchers by bringing them into contact and stimulating discussions with national and international researchers (peers and non-peers) who are active in the field on immuno-imaging and -therapy.

 

More in particular, the following topics will be provided:

 




  • Overview of molecular imaging modalities, including nuclear (PET/SPECT), optical (Fluorescence and Bioluminescence) and magnetic resonance imaging techniques.


  • Overview of current clinical practices in nuclear medicine departments


  • Overview of biotechnological applications of antibodies, antibody-fragments and nanobodies


  • Overview of the concepts in the development of molecular tracers, with focus on immuno-tracers and nanobody-based tracers


  • Introduction to radiochemical strategies towards development of radio-tracers


  • Introduction to the concept of theranostics and targeted radionuclide therapy


  • Overview of optical imaging applications, with focus on interventional molecular imaging


  • Insights in the process of translating a molecular imaging technology towards the clinic and towards industry


  • Highlight of important novel developments in the field, presented by international and/or national experts.


 

Additional info

The core of this course is a one-week workshop that consists of lectures, hands-on sessions and discussion fora. This workshop usually takes place in the last week of April at the Health Campus. A detailed program of the workshop, including the content and timing of the various lectures, and a biosketch of each lecturer will be provided beforehand. The presence at this workshop is obligatory.

In addition, a 3h introductory lecture (obligatory presence) will be given one week before the start of the workshop, and a 4h interactive session (optional presence) is foreseen one week after the workshop to provide feedback on the course content

All lectures and hands-on sessions will be accompanied with powerpoint presentations: a printout of the handouts of these presentations will be provided before the start of the lectures. They will also be provided digitally by uploading them on Pointcarré.

Learning Outcomes

Algemene competenties



  • To understand the important concepts of molecular imaging and therapy discussed during the lectures:


    • Advantages and shortcomings of the different molecular imaging modalities and equipment


    • Engineering and application of molecular tracers, taking into account biological, chemical, pharmaceutical, medical and economical aspects




  • To be able to apply these concepts for the design of molecular tracers for specific medical needs (what, how, why?)


  • To gain competences in scientific communication with peers and non-peers


    • Asking scientific questions during seminars


    • Taking part in face-to-face scientific discussions during informal contact moments and hands-on sessions




  • To be able to summarize, critically evaluate and present a scientific paper relating to various aspects presented and discussed during the seminar.

Grading

The final grade is composed based on the following categories:
Oral Exam determines 50% of the final mark.
PRAC Presentation determines 25% of the final mark.
SELF Practical Assignment determines 25% of the final mark.

Within the Oral Exam category, the following assignments need to be completed:

  • with written preparation with a relative weight of 50 which comprises 50% of the final mark.

    Note: Schriftelijk examen met mondelinge verdediging

Within the PRAC Presentation category, the following assignments need to be completed:

  • presentatie with a relative weight of 25 which comprises 25% of the final mark.

    Note: Presentatie

Within the SELF Practical Assignment category, the following assignments need to be completed:

  • deelname WPO with a relative weight of 25 which comprises 25% of the final mark.

    Note: Actieve deelname WPO

Additional info regarding evaluation

Students will be evaluated on 3 aspects: 1) active participation in the workshop; 2) presentation of a self-chosen scientific paper dealing with several aspects related to the course content; 3) knowledge of the course content. Students will not be scored for the correct use of the english language during the workshop, scientific presentation or oral examination.

 

1) 1/4 of the grading will depend on the course participant's active participation. The tutor who will be present during all workshop sessions will make this evaluation. The tutor will evaluate the ability of the student to ask critical questions, participate in discussions with peers and lecturers during lectures, hands-on sessions and a poster session (where non-VUB workshop participants present their personal research field).

2) 1/4 of the grading will depend on the presentation of a self-chosen scientific paper to the course lecturers. At least 3 workshop lecturers will be present during this presentation to participate in the evaluation. The student is asked to present in a short powerpoint presentation the key aspects of a scientific paper that involves topics that were discussed during at least two workshop lectures. The student will be graded on presentation skills, attitude, introduction of the topic, presentation layout, correctness of the presented data and interpretation of the conclusions

3) 1/2 of the grading will depend on the knowledge of the course content. This will be evaluated during an oral exam that will take place after the presentation of the self-chosen scientific paper. Again, at least 3 lecturers will participate in the evaluation, and a mean grading of all examinators will be calculated. The student will be examined on knowledge of the whole course content, not only on the topics that were presented in the self-chosen scientific publication.

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Biomedical Sciences: Management and Business (only offered in Dutch)
Master of Biomedical Sciences: Clinical Biomedical Sciences (only offered in Dutch)
Master of Biomedical Research: Standaard traject
Master of Teaching in Health Sciences: standaard traject (120 ECTS, Etterbeek) (only offered in Dutch)