4 ECTS credits
100 h study time

Offer 1 with catalog number 1018079BNR for all students in the 2nd semester at a (B) Bachelor - advanced level.

2nd semester
Enrollment based on exam contract
Grading method
Grading (scale from 0 to 20)
Can retake in second session
Enrollment Requirements
Om een inschrijving te kunnen nemen voor ‘Biomedische Genetica’ moet men geslaagd zijn voor het eerste jaar Bachelor Biomedische Wetenschappen EN moet men ingeschreven of geslaagd zijn voor ‘Onwikkelingsbiologie en embryologie’, ‘De Cel: Biomoleculen & metabolisme’ en ‘De Cel: Moleculaire biologie en signaaltransductie’ OF Voor de studenten ingeschreven in het verkort bachelorprogramma Biomedische wetenschappen geldt : Om een inschrijving te kunnen nemen voor ‘Biomedische Genetica’ moet men ingeschreven of geslaagd zijn voor ‘Onwikkelingsbiologie en embryologie’, ‘De Cel: Biomoleculen & metabolisme’ en ‘De Cel: Moleculaire biologie en signaaltransductie’
Taught in
Faculteit Geneeskunde en Farmacie
Basis (bio-) medische wetensch
Educational team
Karen Sermon (course titular)
Activities and contact hours

26 contact hours Lecture
12 contact hours Seminar, Exercises or Practicals
20 contact hours Independent or External Form of Study
Course Content

This course mainly concerns genetics in the human, how mistakes in the genome can lead to genetic disease, and how these mistakes can be detected, and possibly even how they can be treated.

A first series of subjects treated form the basis for a better understanding of applied biomedical genetics: gene structure and –function, chromosomes and genes in genetic disease, genome structure and genetic variation, searching for genes with a particular function of with mutations in certain diseases, the regulation of gen expression, including epigenetics and imprinting disorders, and research techniques used to achieve this.  The more applied part of biomedical genetics is treated in courses on prenatal and preimplantation diagnosis, farmacogenetics, oncogenetics and gene therapy.  Moreover multifactorial diseases, ie diseases caused by environmental factors as well as genetic factors, and population genetics are treated.  Throughout the course, ethical questions are treated ad hoc.  Two WPOs are spent to solve genetic problems, while a third WPO is dedicated to reading, understand and presenting a scientific article from the field. At the end of the course, a fourth WPO gives the students the opportunity to ask questions concerning the contents of the course, and typical exam questions are solved.

Additional info


Learning Outcomes

General Competencies

At the end of this course, the student has to master the following aspects of biomedical genetics:

· The student knows the structure of the human genome, and understands how this genome multiplies through mitosis as well as meiosis, and how this genome is brought to expression and is translated in active constituents of the cell

· The student knows the causes and consequences of mistakes in the genome, and understands how these can lead to either variation of genetic disease.

· The student knows the difference between chromosomal, monogenic, epigenetic and multifactorial diseases.

· The student knows the methods that are used to investigate the genome, both at the level of the chromosomes as the level of the DNA and the genes, as at the level of RNA (including coding and non-coding RNA)

· The student can integrate the knowledge of genetic disease and research methods that was acquired to solve complex problems. These problems can start from a clinical presentation where the student must formulate a diagnostic method, or a more fundamental question regarding genetic research.

· The student can understand new developments in genetics by reading selected scientific articles 


The final grade is composed based on the following categories:
Other Exam determines 100% of the final mark.

Within the Other Exam category, the following assignments need to be completed:

  • Examen Andere with a relative weight of 100 which comprises 100% of the final mark.

Additional info regarding evaluation

Oral 100 %

Note: the student will receive three questions: one theoretical, one concerning correct use of methodology, and one genetic problem

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Bachelor of Biomedical Sciences: Default track (only offered in Dutch)
Bachelor of Biomedical Sciences: Abridged (only offered in Dutch)