3 ECTS credits
75 h study time

Offer 1 with catalog number 4018337ENR for all students in the 2nd semester of odd academic years (e.g. 2013-2014) at a (E) Master - advanced level.

Semester
biennial: 2nd semester of an odd academic year (e.g. 2013-2014)
Enrollment based on exam contract
Impossible
Grading method
Grading (scale from 0 to 20)
Can retake in second session
Yes
Taught in
English
Faculty
Faculty of Sciences and Bioengineering Sciences
Department
Bio-Engineering Sciences
Educational team
Steven Ballet (course titular)
Activities and contact hours
13 contact hours Lecture
13 contact hours Seminar, Exercises or Practicals
13 contact hours Independent or External Form of Study
Course Content

As is generally known among medicinal chemists the use of peptides as therapeutic agents is associated with drawbacks like rapid metabolism by proteolysis, lack of selectivity due to the conformational flexibility, poor bioavailability and unfavorable absorption. As a result of all these problems inherent to peptides, the concept of “mimicking the peptide” was born. Researchers explored ways to overcome the unfavorable properties of bioactive peptides. Considerable effort was and is still being devoted to the synthesis of Peptidomimetics. This term can be defined as “any compound containing non-peptidic structural elements that is capable of mimicking the biological actions of a natural parent peptide”.

This course offers a general overview of different strategies to mimic peptides. Detailed synthetic pathways and design aspects are considered. The four core areas in peptide mimetics research are addressed:     

  • Side-chain modified peptides
  • Main-chain modified peptides
  • Combined side-main-chain modifications
  • Mimetics incorporating secondary structures

 

A limited amount of Medicinal chemistry aspects will be included to create a minimal contextual setting.

Course material
Course text (Required) : Peptidomimetics, Lecture notes and powerpoint presentations, Door de prof
Additional info

N/A

Learning Outcomes

General Competences

The student can:

  • provide a description of the discussed design strategies
  • apply the discussed design strategies
  • elaborate on and discuss the studied synthetic pathways and concomitant reaction mechanisms

Grading

The final grade is composed based on the following categories:
Oral Exam determines 50% of the final mark.
Written Exam determines 50% of the final mark.

Within the Oral Exam category, the following assignments need to be completed:

  • oral exam with a relative weight of 1 which comprises 50% of the final mark.

Within the Written Exam category, the following assignments need to be completed:

  • written exam with a relative weight of 1 which comprises 50% of the final mark.

Additional info regarding evaluation

Mondeling examen met schriftelijke voorbereiding en schriftelijk examen 

Het examen zal zowel theoretische als praktische problemen behandelen.  

De scores worden als volgt gewogen: theorie x 1 + synthese x 1.

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Medical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Molecular Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Cell and Gene Biotechnology: Agrobiotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Food Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Chemical Biotechnology (only offered in Dutch)
Master of Bioengineering Sciences: Chemistry and Bioprocess Technology: Biochemical Biotechnology (only offered in Dutch)