5 ECTS credits
150 h study time
Offer 1 with catalog number 1020459ANR for all students in the 1st semester
at
a (A) Bachelor - preliminary level.
- Semester
- 1st semester
- Enrollment based on exam contract
- Impossible
- Grading method
- Grading (scale from 0 to 20)
- Can retake in second session
- Yes
- Taught in
- Dutch
- Faculty
- Faculteit Geneeskunde en Farmacie
- Department
- Pathology/molecular and cellular medicine
- Educational team
- Mark Van De Casteele
Nick Devoogdt
(course titular)
Linus Donvil
Julie Vandewalle
- Activities and contact hours
- 30 contact hours Lecture
15 contact hours Seminar, Exercises or Practicals
10 contact hours Independent or External Form of Study
- Course Content
The course ‘Metabolism’ contains two main subparts:
- essential concepts of metabolism and metabolic energy
-integration of bodily metabolism
The first part of 'Metabolism' explains the synthesis of large complex biomolecules from simple building blocks (anabolism) and the production of metabolic energy from degradation and oxidation of biomolecules (catabolism). Specific learning units are devoted to the general metabolic principles of carbohydrates, lipids, proteins and nucleotides. In the final part the integration of metabolism is discussed at the level of tissues, organs and the entire human organism.
The course content is organized in a conceptual rather than a purely descriptive manner. In addition, the course is (bio)medically oriented as exemplified by the choice of topics with immediate relevance to the pathogenesis, diagnosis, treatment and prevention of important human disorders.
- Course material
- Handbook (Required) : Leerboek metabolisme en voeding, F.C. Schuit, 3de herziene druk, Bohn Stafleu Van Loghum, 9789036823579, 2019
Digital course material (Required) : Slides, B. Van der Auwera, M. Van de Casteele, Canvas
Handbook (Recommended) : Molecular Biology of the Cell, B. Alberts, A. Johnson, J. Lewis, D. Morgan, M. Raff, K. Roberts, P. Walter, 6de, Garland Science, 9780393884852 , 2023
Handbook (Recommended) : Biochemistry, J.M. Berg, J.L. Tymoczko, L. Stryer, 9de, W.H. Freeman, 9781319498504, 2023
Course text (Required) : De cel: Biomoleculen en Metabolisme, Deel glucosemetabolisme, M. Van de Casteele, VUB, 2220170000497, 2021
- Additional info
Specific information about the organisation of the course can be found on Canvas.
- Learning Outcomes
-
Algemene Competenties
The student
- Knows the basic principles of thermodynamics in energy metabolism
- Knows the pathways of carbohydrate, amino acid, lipid, cholesterol and nucleotide metabolism and their regulation and can give examples of inborn errors of metabolism for the most important pathways
- Can explain the integration of different metabolic pathways and their hormonal regulation during feeding, in the postprandial state and in starvation
- Can define obesity and diabetes and knows the role of carbohydrate, amino acid and lipid metabolism and its (dys)regulation in the pathogenesis of diabetes and obesity
- Grading
-
The final grade is composed based on the following categories:
Written Exam determines 80% of the final mark.
PRAC Lab Work determines 10% of the final mark.
SELF Paper determines 10% of the final mark.
Within the Written Exam category, the following assignments need to be completed:
- Examen Schriftelijk
with a relative weight of 80
which comprises 80% of the final mark.
Note: Kennis en inzicht van de student(e) in de leerstof van de hoorcolleges worden getoetst via een schriftelijk examen (40-tal meerkeuzevragen met 5 afleiders per vraag zonder giscorrectie, en een vijftal korte open vragen).
Within the PRAC Lab Work category, the following assignments need to be completed:
- WPO
with a relative weight of 10
which comprises 10% of the final mark.
Note: Het practicum Metabolisme wordt geëvalueerd op basis van een schriftelijke toets voorafgaand aan het practicum, en van een laboverslag. Indien de student(e) ten minste 12/20 behaalde op het onderdeel ‘practicum Metabolisme’ dan kan dit cijfer naar een volgend academiejaar worden overgedragen. De student(e) die dit onderdeel toch wenst te hernemen, stuurt een e-mail naar de titularis uiterlijk voor aanvang van de praktische labosessies van het lopend academiejaar. Eenmaal de student(e) heeft gemeld dat hij/zij wil afzien van zijn/haar WPO-deelcijfer uit een vorig academiejaar, verliest hij/zij onherroepelijk dit deelcijfer. Aanwezigheid is verplicht voor de praktische labosessies. Afwezigheden dienen gewettigd te worden met een attest. Het examenonderdeel WPO Metabolisme (labowerk) kan niet worden hernomen in tweede zittijd.
Within the SELF Paper category, the following assignments need to be completed:
- individuele opdracht paper
with a relative weight of 10
which comprises 10% of the final mark.
Note: Het deel ZELF bestaat uit een literatuuropdracht over een metabole ziekte (max. 5 pagina's, inclusief referenties)
- Additional info regarding evaluation
For the course 'The Cell: Biomolecules and Metabolism' each student will receive a global mark that will be included in the final grade, taking into account the relative proportion of the course in the curriculum. The global score for this course includes both the scores for (1) topics related to the lectures/seminars, (2) the practical lab sessions (written test and lab reports), and (3) an individual written assignment (discussion of a human metabolic disorder on max. 5 pages including references). This global score reflects the relative workload for each part.
The written exam in January is composed of both multiple choice questions without account for guessing, and short open questions.
- Allowed unsatisfactory mark
- The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.
Academic context
This offer is part of the following study plans:
Bachelor of Biomedical Sciences: Abridged BMLT (only offered in Dutch)