25 ECTS credits
750 h study time

Offer 1 with catalog number 6021785FNR for all students in the 1st and 2nd semester at a (F) Master - specialised level.

Semester
1st and 2nd semester
Enrollment based on exam contract
Impossible
Grading method
Pass/Non pass
Can retake in second session
Yes
Taught in
Dutch
Partnership Agreement
Under interuniversity agreement for degree program
Faculty
Faculteit Geneeskunde en Farmacie
Department
Supporting clinical sciences
Educational team
Ilse Weets (course titular)
Activities and contact hours
60 contact hours Seminar, Exercises or Practicals
675 contact hours Independent or External Form of Study
Course Content

Clinical biology is the domain of medicine that focuses on performing laboratory dissections on biological fluids or cell material for the prediction, prognosis and monitoring of diseases in children and adults. The clinical biologist gives professional scientifically funded advice concerning the responsible use and interpretation of clinical biological tests. He/she vouches for the quality of dissections from the sampling until the reporting to the requesting physician and for the organization and development of the laboratory.  

After receiving a lower education in the 3 subdomains (hematology, clinical chemistry and radio-immunology & microbiology), the ASO will follow a higher education, either polyvalent or more targeted towards 1 or 2 sub-specialisms, according to the internships in these subdisciplines.  

Apart from the classical diagnostic research, the general clinical biologist plays a role in diagnostic evaluative sciences: evaluate the health systems and care patterns, analysis of (new) diagnostic and therapeutic strategies, including analysis, cost-efficiency and cost-effectivity, quality analysis, medico-economic analyses, “outcome research”, decisional analyses, new methods and their evaluation.  

During the MaNaMa, the ASO acquires the necessary scientific knowledge, skills and attitudes for the future professional career. These are indispensable for professional formation, as legally determined by the accreditation committee. See OO-fiche ‘Skills in Clinical Biology’.   

The ASO completes his/her training in the sub-specialisms or sub-specializes in 1 of these.  

Apart from the contents of part 1 of this course (see OO-fiche Problem-Solving capability, part 1), which is also a part of the exam, the following topics are covered: 

  1. General 

  • Data management: computerized management of medical data, data protection, data transmission, archiving, report validation, (electronic signature), basic aspects of databases, spreadsheets, internet… 

  • Laboratory management 

 

  1. Clinical chemistry higher education 

  • Further enhance the general knowledge in clinical chemistry & radio-immunology (substrates, electrolytes, pH and blood gasses, enzymes, specific proteins) in the blood and other fluids 

  • Laboratory robotic principles and automatization strategies 

  • Causes of (positive and negative) analytical interferences in biochemical dosages: knowledge on, be able to detect and clear) 

  • Biochemical physiopathology of the organs 

  • Further enhance knowledge from basic education 

  • Toxicological and therapeutic drug monitoring, including advices (optional) 

  • Hormonology/endocrinology- tumor markers 

  • Allergy tests and auto-antibodies 

  • Vitamins, minerals and bone metabolisms  

  • (congenital) metabolic diseases (optional) 

  • Perform test evaluations; fine-tuning of new parameters 

  • Participate in scientific research; prepare scientific publications; active participation in symposia/presentations 

  • Quality control in clinical chemistry 

  • Accreditation in clinical chemistry 

  • Training/guidance of trainees and medical laboratory technicians 

  •  

  • Hematology higher education 

  • Quality control systems in hematology 

  • Hematological pathology: technical aspects, clinical backgrounds and diagnostic strategy 

  • Distinguish between primary and secondary hematological diseases 

  • Hematological oncology: classification and global treatment pathways of these diseases, including bone marrow transplant 

  • Polyglobulies and hemolytic anemias  

  • Cytomorphological investigation: autonomously evaluate peripheral blood, bone marrow and bodily fluids of non-hematological and hematological diseases 

  • Hematological analyzers 

  • Flowcytometry  

  • Hematological biochemistry 

  • Molecular diagnostics 

  • Coagulation and hemostasis 

  • Immunohematology 

  • Knowledge of the functioning of a hospital blood bank, transfusion committee and haemovigilance 

  •  

  • Microbiology higher education 

  • Mycology 

  • Mycobacteriology 

  • Virologic diagnostics (infectious serology (all parameters, confirmation tests, avidity tests), viral cultures, molecular diagnosti

  • cs); validation of virologic tests; virologic knowledge and advising 

  • Hospital epidemiology 

  • Antibiotic-stewardship and infection control (hospital hygiene) 

  • Perform test evaluation; fine-tuning of new parameters 

  • Participate in scientific research; prepare scientific publications. Actice participation in symposia/presentations 

  • Quality control in microbiology 

  • Accreditation microbiological lab 

  • Training/guidance of trainees and medical laboratory techniques 

  • Involvement/awareness of the economic aspects of microbiological diagnostics 

Course material
Digital course material (Required) : ​iProva (documentbeheersysteem van UZ-Brussel), in het bijzonder "Kwaliteitshandboek medische laboratoria en banken MLM" (= “KHB”) en andere procedures vermeld in het punt “Inhoud”
Handbook (Recommended) : Hoffbrand's Essential Haematology, A. Victor Hoffbrand, Paul A. H. Moss, 8de, Wiley-Blackwell, 9781119495901, 2019
Handbook (Recommended) : Dacie and Lewis Practical Haematology, Bain - Bates - Laffan, 12de, Elsevier, 9780702066962, 2016
Handbook (Recommended) : Tietz fundamentals of clinical chemistry and molecular diagnostics, Nader Rifai Horvath, Andrea Rita, 8de, Elsevier - Health Sciences Division, 9780323530446, 2019
Handbook (Recommended) : Clinical Microbiology Procedures Handbook, 3 Volume Set, Amy.L. Leber, 4de, American Society For Microbiology, 9781555818807, 2016
Digital course material (Required) : Digitaal cursus materiaal (vrij beschikbaar in het UZ-Brussel): Up-to-Date (vrij beschikbaar in het UZ-Brussel), IGGI (vrij beschikbaar in het UZ-Brussel), IDSA richtlijnen (vrij beschibaar op de net), andere evidence based databasen
Digital course material (Required) : Internationale richtlijnen voor klinische laboratoria: CLSI (beschikbaar via L: drive in UZ-Brussel), EUCAST (website vrij beschikbaar),
Digital course material (Required) : Praktijkrichtlijn voor het opzetten van een kwaliteitshandboek in de erkende laboratoria voor klinische biologie werkzaam binnen het kader van het Erkenningsbesluit”, beschikbaar op de website van het Wetenschappelijk Instituut voor Volksgezondheid
Additional info

WORKING METHODS 

The final objectives are met in practice by: 

  • Multidisciplinary staff meetings (1h/week) 

  • Staff meetings in the discipline (1h/week) 

  • Quality meetings (1h/week) 

  • Sessions for technical skills 

  • Bench-side and bed-side teaching 

  • Case discussions 

  • Room tour 

  • Supervised consultation or advices (e.g. thrombo tests, blood collection, infectiology) 

For the sub-specialism in microbiology, it is recommended to follow the interuniversity special training in antibiotic policy and to start the MaNaMa in Hospital hygiene. 

For the sub-specialism in clinical chemistry & radio-immunology, it is recommended to follow the training for the in vitro use of radionuclides concerning clinical biology. 

For the sub-specialism in hematology, it is recommended to follow the Belgian Hematology Society training program.  

The ASO is actively involved in laboratory analyses, including control of the pre-analytical phase and validation of produced results (post-analytical phase). The ASO remains critical and complements the practical knowledge by learning background theory from the various information sources that are provided. 

Learning Outcomes

knowledge

OLR 1: Has acquired profound medical knowledge and insights in the specialism (M, W).  

OLR 19: Satisfies the general and specific final objectives, inherent to the specialism, concerning diagnostics and syndromes/diseases (M, W).  

insight

OLR 3: Has further enhanced the problem-solving capacity and applies this in practice (M, W).  

OLR 6: Knows the possibilities of other health care disciplines and the expertise of others in patient health care (C, M). 

skills

OLR 2: Has acquired the skills, inherent to the specialism, and applies these correctly. 

OLR 13: Can participate in the organization of health care and in the policy of the department (Ma).  

Attitudes

OLR 15: Takes into account the economic aspects of medicine and uses the available resources accordingly, avoiding under- and overuse (M).  

OLR 17: Keeps further developing and improving own skills. 

OLR 18: Is capable of introducing “standards of care” and quality requirements with regard to the different aspects of formulating one’s own specialism (M, Ma).  

Grading

The final grade is composed based on the following categories:
Oral Exam determines 50% of the final mark.
SELF Practical Assignment determines 50% of the final mark.

Within the Oral Exam category, the following assignments need to be completed:

  • Jury examen with a relative weight of 50 which comprises 50% of the final mark.

    Note: examen via ondervraging door de jury Klinische Biologie over documenten, standard operating procedures uit kwaliteitshandboek

Within the SELF Practical Assignment category, the following assignments need to be completed:

  • Portfolio with a relative weight of 50 which comprises 50% of the final mark.

    Note: portfolio met functioneringsgesprek

Additional info regarding evaluation
  • Portfolio with performance interview (50%). 

  • Exam with questioning by jury of Clinical Biology on documents and SOPs from the quality handbook (50%).  

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Specialist Medicine: Clinical Biology (only offered in Dutch)