6 ECTS credits
180 h study time
Offer 1 with catalog number 6021910ENR for all students in the 1st and 2nd semester at a (E) Master - advanced level.
COURSE CONTENT
Radiobiology: cf. Book of Eric Hall
Physics and chemistry of radiation absorption
DNA strand breaks and chromosomal aberrations
Cell survival curves
Radiosensitivity and cell age in the mitotic cycle
Repair of radiation damage and the dose-rate effect
Oxygen effect and reoxygenation
Linear energy transfer and relative biological effectiveness
Acute effects of total-body irradiation
Radioprotectors
Radiation carcinogenesis
Hereditary effects of radiation
Effects of radiation on the embryo and fetus
Radiation cataractogenesis
Doses and risks in diagnostic radiobiology, interventional radiobiology and cardiology and nuclear medicine
Radiation protection
Molecular techniques in radiobiology
Cancer biology
Dose-response relationships for model normal tissues
Clinical response of normal tissues
Model tumor systems
Cell, tissue and tumor kinetics
Time, dose and fractionation in radiotherapy
Predictive assays
Alternative radiation modalities
Radiosensitizers and bioreductive drugs
Gene therapy
Chemotherapy agents from the perspective of the radiation biologist
Hyperthermia
Systemic treatments:
Chemotherapy
Biologic therapies & small molecules
Hormonal treatments
Pharmacokinetics & pharmacodynamics
Cancer biology:
Biologic basis of radiation therapy
Molecular cancer and radiation biology
Molecular pathophysiology of tumors
WORKING METHODS
Students prepare the practical sessions in the reference work (SELF). The content is discussed afterwards during the practical sessions (PRAC).
OLR 1: Has acquired profound medical knowledge and insights in the specialism (M, W).
OLR 10: Relies on scientific knowledge, obtained through clinical scientific research (W).
OLR 11: Is capable of interpreting and analyzing the offered scientific knowledge critically and can correctly and clearly report on it (W).
OLR 3: Has further enhanced the problem-solving capacity and applies this in practice (M, W).
OLR 12: Perpetuates a critical, scientific attitude (W).
OLR 19: Satisfies the general and specific final objectives, inherent to the specialism, concerning diagnostics and syndromes/diseases (M, W).
The final grade is composed based on the following categories:
Other Exam determines 100% of the final mark.
Within the Other Exam category, the following assignments need to be completed:
Portfolio with performance interviews and an assessment interview at the end, level expert (100%).
PASS/FAIL
This offer is part of the following study plans:
Master of Specialist Medicine: Radiotherapy and Oncology (only offered in Dutch)