6 ECTS credits
180 h study time

Offer 1 with catalog number 6021910ENR for all students in the 1st and 2nd semester at a (E) Master - advanced level.

Semester
1st and 2nd semester
Enrollment based on exam contract
Impossible
Grading method
Pass/Non pass
Can retake in second session
Yes
Taught in
Dutch
Partnership Agreement
Under interuniversity agreement for degree program
Faculty
Faculty of Medicine and Pharmacy
Department
Clinical sciences
Educational team
Mark De Ridder (course titular)
Activities and contact hours
50 contact hours Seminar, Exercises or Practicals
120 contact hours Independent or External Form of Study
Course Content

COURSE CONTENT 

Radiobiology: cf. Book of Eric Hall 

  • Physics and chemistry of radiation absorption 

  • DNA strand breaks and chromosomal aberrations 

  • Cell survival curves 

  • Radiosensitivity and cell age in the mitotic cycle 

  • Repair of radiation damage and the dose-rate effect 

  • Oxygen effect and reoxygenation 

  • Linear energy transfer and relative biological effectiveness 

  • Acute effects of total-body irradiation 

  • Radioprotectors 

  • Radiation carcinogenesis 

  • Hereditary effects of radiation 

  • Effects of radiation on the embryo and fetus 

  • Radiation cataractogenesis 

  • Doses and risks in diagnostic radiobiology, interventional radiobiology and cardiology and nuclear medicine 

  • Radiation protection 

  • Molecular techniques in radiobiology 

  • Cancer biology 

  • Dose-response relationships for model normal tissues 

  • Clinical response of normal tissues 

  • Model tumor systems 

  • Cell, tissue and tumor kinetics 

  • Time, dose and fractionation in radiotherapy 

  • Predictive assays 

  • Alternative radiation modalities 

  • Radiosensitizers and bioreductive drugs 

  • Gene therapy 

  • Chemotherapy agents from the perspective of the radiation biologist 

  • Hyperthermia 

 

Systemic treatments: 

  • Chemotherapy 

  • Biologic therapies & small molecules 

  • Hormonal treatments 

  • Pharmacokinetics & pharmacodynamics 

 

Cancer biology: 

 

  • Biologic basis of radiation therapy 

  • Molecular cancer and radiation biology 

  • Molecular pathophysiology of tumors 

Course material
Handbook (Required) : Radiobiology for the Radiologist, Eric J. Hall, Amato J. Giaccia, 7de, Dienst Radiotherapie van het UZ Brussel, 9781608311934, 2011
Handbook (Required) : Principles and Practice of Radiation Oncology -(ch. 2 - 4), (ch. 2 - 4), Perez and Brady's, 6de, Dienst Radiotherapie van het UZ Brussel, 9781451116489, 2013
Digital course material (Required) : Geselecteerde wetenschappelijke artikels
Additional info

WORKING METHODS 

Students prepare the practical sessions in the reference work (SELF). The content is discussed afterwards during the practical sessions (PRAC).  

 

Learning Outcomes

Knowledge

OLR 1: Has acquired profound medical knowledge and insights in the specialism (M, W).  

Insights

OLR 10: Relies on scientific knowledge, obtained through clinical scientific research (W).  

OLR 11: Is capable of interpreting and analyzing the offered scientific knowledge critically and can correctly and clearly report on it (W).  

Skills

OLR 3: Has further enhanced the problem-solving capacity and applies this in practice (M, W).  

Attitudes

OLR 12: Perpetuates a critical, scientific attitude (W).  

OLR 19: Satisfies the general and specific final objectives, inherent to the specialism, concerning diagnostics and syndromes/diseases (M, W).  

Grading

The final grade is composed based on the following categories:
Other Exam determines 100% of the final mark.

Within the Other Exam category, the following assignments need to be completed:

  • Portfolio with a relative weight of 100 which comprises 100% of the final mark.

    Note: portfolio met functioneringsgesprekken en evaluatiegesprek aan het einde van het niveau expert (100%)

Additional info regarding evaluation

Portfolio with performance interviews and an assessment interview at the end, level expert (100%).  

PASS/FAIL 

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Specialist Medicine: Radiotherapy and Oncology (only offered in Dutch)