4 ECTS credits
120 h study time
Offer 1 with catalog number 4022182DNR for all students in the 1st semester at a (D) Master - preliminary level.
Protection and Exploitation of Research Results
• Exploitation of biomedical research and the valorisation of research results at university
• Introduction to intellectual property rights
• Introduction to patents, patent process and patent searching
• Introduction to agreements, including confidentiality, material transfer and R&D contracts
• Introduction to start-ups: general principles, parties involved, financing
Radioactivity, physical and chemical safety:
• Basics of ionizing radiation
• Interaction of radiation with matter, measuring methods for radioactivity, dosimetry
• Production and use of ionizing radiation in biomedical research
• Prevention approach of physical and chemical risks in the laboratory
• Radiation protection in biomedical research and regulations for waste disposal
• General regulations
• Laboratory visits
Biosafety:
• Working with pathogens and genetically modified organisms: what is biosafety and why; contained use and deliberate release; relevant legislation in Belgium
• Risk assessment: hazards and risks; classification of dangerous organisms; risk-bearing manipulations in the lab; a clinical trial as a practical example
• Working with pathogens and GMOs in practice: containment versus cleanroom practices: biosafety and/or quality?
Statistics
Part 1: General linear models
1. Simple linear regression
2. Correction for confounders: Multi-way analysis of covariance (ANCOVA)
3. Repeated measures and cross-over designs: Mixed AN(C)OVA
Part 2: Generalized linear models
4. Survival analysis: Cox regression
5. Predicting a dichotomous variable: Logistic regression
Powerpoint slides
Demonstration searching patent databases
• The student has knowledge of the regulations regarding clinical research and insight into the practical preparation and conduct of clinical studies. Basic insight in industrial valorisation of academic research results, i.e. in the protection of intellectual property, patenting, contract research with industry and start-ups
• The student can guarantee personal safety of laboratory personnel, environmental protection and the quality of scientific and clinical research.
• The student knows how to work safely with ionizing radiation, chemicals and biological material in biomedical and clinical laboratories. The student has knowledge and understanding of the scientific applications of ionizing radiation and radioactive substances.
• The student adopts some state-of-the-art methods currently applicable in empirical research for confirming and validating research objectives. The selection of techniques provided form the foundation of other methods in the domain of general and generalized linear models such that the student can independently consult statistical literature to learn other techniques based on similar principles.
The final grade is composed based on the following categories:
Written Exam determines 67% of the final mark.
SELF Teamwork determines 33% of the final mark.
Within the Written Exam category, the following assignments need to be completed:
Within the SELF Teamwork category, the following assignments need to be completed:
Each part is evaluated separately. The total mark is a weighted average of the marks corresponding to each part.
Statistics (weight 3): Group assignment (approx. 4 students) analyse a given dataset. Its conclusions are reported through a paper of maximally 5 A4 pages in the style of a scientific research publication. On top of that, each group searches a recently published (recent 2 years) research article in their field of interest. A critical essay is written of maximally 1 A4 page where the completeness of the research methodology of the selected publication is assessed. To discriminate among group members, each group member receives 5 minutes time to discuss the primary findings of the submitted reports. The initial mark of the written report corresponds to the average of the individual marks over the group members.
Protection and exploitation of research results (weight 2): Multiple choice exam of approximately 35 questions for which a passing mark is obtained if 62.5% of the questions are correctly answered. As a result, every mark obtained between 0 and 62.5% is normalized to end result between 0 and 10, while marks obtained between 62.5% and 100% is normalized to an end result between 10 and 20.
Radioactivity, physical and chemical safety (weight 2): Open question exam of approximately 2 questions. In addition, one question about an article received during the lectures.
Biosafety (weight 1): Each student receives a problem statement during the lecture. At the exam the student is instructed to propose a solution to the problem where both the problem solving as well as the quality of the reasoning is assessed.
This offer is part of the following study plans:
Master of Biomedical Sciences: Management and Business (only offered in Dutch)
Master of Biomedical Sciences: Clinical Biomedical Sciences (only offered in Dutch)
Master of Biomedical Research: Standaard traject