4 ECTS credits
100 h study time

Offer 1 with catalog number 4012429ENR for all students in the 2nd semester at a (E) Master - advanced level.

Semester
2nd semester
Enrollment based on exam contract
Impossible
Grading method
Grading (scale from 0 to 20)
Can retake in second session
Yes
Enrollment Requirements
Om een inschrijving te kunnen nemen voor 'Toegepaste toxicologie' moet men geslaagd zijn voor alle opleidingsonderdelen van de oude bachelor FW EN ingeschreven of geslaagd zijn voor 'Algemene Toxicologie' voor de opleiding Farmaceutische Wetenschappen OF ingeschreven zijn in de Master Specialistische Geneeskunde
Taught in
Dutch
Faculty
Faculteit Geneeskunde en Farmacie
Department
Pharmaceutical and Pharmacological Sciences
Educational team
Joery De Kock (course titular)
Activities and contact hours

20 contact hours Lecture
20 contact hours Seminar, Exercises or Practicals
Course Content
HOC
This course is an extension of the course General Toxicology in which the basic principles and risk evaluation analysis for chemicals are explained. Here, a number of more specialised topics are studied in depth.
The course contains the following topics:
- Alternative methods to refine, reduce and/or replace animal experiments
- Natural Toxins
- Endocrine disruptors
- Biopharmaceutics
- Pesticides
- Risk substances (heavy metals, pollution and incineration gasses, solvents, ...)
 
 
 
WPO
In the WPO, students will work in teams on a predefined toxicological topic during the whole semester. The students will also perform a practical procedure in the context of toxicity testing.
Course material
Digital course material (Required) : Toegepaste toxicologie, een syllabus is beschikbaar, Profn Rogiers en Vanhaecke
Practical course material (Required) : Werkcollege nota’s zijn beschikbaar, Profn Rogiers en Vanhaecke
Practical course material (Recommended) : Toegepaste en moleculair toxicologische handboeken
Additional info

- Attendance to the practical courses is compulsory.

- Background information and protocols must be studied before the start of each lab day.

Learning Outcomes

General competencies

The student:

- knows the difference between "hazard" and "risk" and can apply this principle to different classes of risk substances

- knows the 3R principle of Russell and Burch and can apply this principle on new test methods

- knows what “adverse outcome pathways” (AOP) are and can apply this concept

- searches, reads and understands scientific articles concerning the discussed topics of the WPO

- writes together with the other team members a scientific article according to the acquired knowledge concerning a predefined topic

- can practically perform toxicity tests

- knows how the test methods that were discussed during the HOC and WPO work ((bio)chemical and biological principles) and can explain this in a scientifically sound way

- knows the different classes of risk substances including heavy metals, pollution and incineration gasses, organic solvents, endocrine disruptors, natural toxins and pesticides

- knows the different types of biopharmaceuticals and new advances medicines (e.g. cell, gene and tissue-engineered products)

- knows and understands the toxicological mechanisms of risk substances and can explain these to others

- is up-to-date with current major toxicological incidents and can give a critical point of view on it

- can perform a basic risk assessment of a medical product or risk substance using the gained knowledge through the HOC and WPO and can critically discuss this with others

Grading

The final grade is composed based on the following categories:
Oral Exam determines 60% of the final mark.
PRAC Teamwork determines 25% of the final mark.
PRAC Presentation determines 10% of the final mark.
PRAC Practical Assignment determines 5% of the final mark.

Within the Oral Exam category, the following assignments need to be completed:

  • Mondeling examen with a relative weight of 1 which comprises 60% of the final mark.

    Note: De evaluatie wordt uitgevoerd aan de hand van een schriftelijke voorbereiding gevolgd door een mondelinge verderzetting.

Within the PRAC Teamwork category, the following assignments need to be completed:

  • Artikel with a relative weight of 1 which comprises 25% of the final mark.

    Note: De evaluatie wordt uitgevoerd aan de hand van scorerooster

Within the PRAC Presentation category, the following assignments need to be completed:

  • Presentatie with a relative weight of 1 which comprises 10% of the final mark.

    Note: De evaluatie wordt uitgevoerd aan de hand van scorerooster

Within the PRAC Practical Assignment category, the following assignments need to be completed:

  • Praktijkopdracht with a relative weight of 1 which comprises 5% of the final mark.

    Note: De evaluatie wordt uitgevoerd aan de hand van verslagen

Additional info regarding evaluation

The evaluation of the WPO occurs during the WPO session.

The final score of the course "Applied Toxicology" at 20 points is calculated as 60% HOC and 40% WPO.

The students will become practically familiar with toxicity testing methods. The report of this practical test will account for 5% of the end score of the course "Applied Toxicology".

In the context of the WPO, student teams will work on a predefined topic about which they will write a scientific paper and present it (±15min). A discussion about this topic will immediately follow the presentation (±10min). At the end of the WPO, the students need to hand in a peer-assessment about the individual contribution of their team members to the team effort. The peer-assessment will be used as correction factor to adjust the team score to each of the individual team members according to their contribution. The evaluation of the team assignment [presentation (10%) + paper (25%)] will account for 35% of the end score of the course "Applied Toxicology".

The oral exam will consist of all the lessons (HOC) and WPO and comprises a written pre-exam and oral explanation. It accounts for 60% of the end score of the course "Applied Toxicology".

When one of these values (HOC or WPO) is lower or equal to 7/20, the lowest mark is communicated and this part has to be redone.

Whenever a student is illegitimate absent during the practical courses, he/she has to follow the WPO session again during the next academic year and will as such be automatically referred to the 1st exam session of the next academic year.

Allowed unsatisfactory mark
The supplementary Teaching and Examination Regulations of your faculty stipulate whether an allowed unsatisfactory mark for this programme unit is permitted.

Academic context

This offer is part of the following study plans:
Master of Biomedical Sciences: Biomedical Research (only offered in Dutch)
Master of Teaching in Health Sciences: standaard traject (120 ECTS, Etterbeek) (only offered in Dutch)